Advances in Prostaglandin and Leukotriene Research: Basic by Oliver Werz, Jenny Klemm, Olof Rådmark, Bengt Samuelsson

By Oliver Werz, Jenny Klemm, Olof Rådmark, Bengt Samuelsson (auth.), Bengt Samuelsson, R. Paoletti, Giancarlo C. Folco, E. Granström, S. Nicosia (eds.)

This quantity is the complaints of the eleventh foreign convention on Advances in Prostaglandin and Leukotriene examine: easy technological know-how and New scientific functions, held in Florence, Italy, on June 4-8, 2000, which maintains the culture of protecting either simple and medical features of prostaglandin and leukotriene study.

At this assembly specific emphasis was once given to the capability program of the radical COX-2 inhibitors, the genetics of bronchial asthma in relation to the creation of leukotrienes, and novel mobile networks for the creation of leukotrienes and lipoxins.

Traditionally, as has been performed in earlier conferences of this sequence, a large amount of new fabric used to be offered and mentioned this yr, with specific cognizance given to the latest medical data.

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Additional info for Advances in Prostaglandin and Leukotriene Research: Basic Science and New Clinical Applications

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Ionophores (increase intraceHular Ca2+) are effective, and Ca2+ also activates 5LO in vitra. 5LO binds Ca2+ in a reversible manner with a Kd dose to 6 11M and maximum binding around two Ca2+ per 5LO [1]. While examining the Ca2+ binding site on 5LO, we noticed similarity between the 5LO N-terminal domain, and calcium binding C2-domains of for example cPLA2• Here, we describe that the N-terminal domain of 5LO binds calcium and mediates calcium stimulation of enzyme activity. 7, Molsoft LLC). In support ofthe model (Figure 1) residues not conserved between 5LO and 15LO, as weH as gaps, are found mainly in the loops connecting the eight ß-strands.

J Biol Chem 1996;271: 12076-81. Du H, Roy AL, Roeder RG. Human transcription factor USF stimulates transcription through the initiator elements of the HIV-l and the Ad-ML promoters. EMBO J 1993;12:501-11. Seto E, Shi Y, Shenk T. YYl is an initiator sequence-binding protein that directs and activates transcription in vitro. Nature 1991;354:241-45. Miller 11, Bieker JJ. A novel, erythroid cell-specific murine transcription factorthat binds to the CACCC element and is related to the Kruppel family of nuclear proteins.

15719-24. Bhattaeharya M, Peri K, Almazan G, et. al. Nuclear loealization of prostagiandin E2 reeeptors. Proe Natl Aead Sei USA 1998;95:15792-97. Provost P, Samuelsson B, Radmark O. Interaetion of5-lipoxygenase with eellular proteins. Proe Natl Aead Sei USA 1999;96: 1881-85. CALCIUM BINDING SITE OF 5-LIPOXYGENASE Tove Hamrnarberg, Patrick Provost, Konda Veera Reddy, Bengt Persson, and 0 lof Rädmark 5-lipoxygenase (5LO) catalyzes the formation of leukotriene A4 from arachidonic acid. Factors determining 5LO enzyme activity are calcium, phosphatidylcholine (membranes), ATP, the ceHular redox status, and phosphorylation events.

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