Advances in Spinal Stabilization by L. Dade Lunsford, Brian R. Subach, Gerald E. Rodts

By L. Dade Lunsford, Brian R. Subach, Gerald E. Rodts

Dramatic adjustments in spinal stabilization have taken position within the final years and the speed of switch maintains to speed up. This quantity is a superb reflect of the evolution of spinal stabilization. It brings jointly the most recent and such a lot finished stories in minimally-invasive and novel surgical ways and spinal stabilization suggestions. Highlights in new biomaterials together with radiolucent, bioresorbable, and conventional titanium are mentioned via specialists. organic advances together with using bone morphogenetic protein in anterior lumbar interbody fusion in addition to computer-assisted image-guided surgical strategies are proven. The part on instrumentation and method represents the main updated advances in surgical strategy and administration of spinal issues. Illustrations integrated in each one bankruptcy rfile those very good papers. since it is a needs to for all surgeons appearing spinal surgical procedure to maintain updated during this fast-paced box this booklet is imperative.

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High-molecular-weight cationic polymers, such as poly-L-lysine, poly-L-ornithine, polyethylenimine, and chitosan, can improve DNA delivery to cells via nonspecific absorptive uptake [67, 68]. Various synthetic polymers can also be utilized to improve cellular transduction rates and can be designed to be biodegradable, thermosensitive, and biocompatible [69]. Polymers can also be constructed with targeting ligands, such as antibodies, transferrin, and asialoglycoprotein to improve tissue specificity.

Cheng SL, Lou J, Wright NM, Lai CF, Avioli LV, Riew KD: In vitro and in vivo induction of bone formation using a recombinant adenoviral vector carrying the human BMP-2 gene. Calcif Tissue Int 2001;68:87–94. Musgrave DS: Human skeletal muscle cells in ex vivo gene therapy to deliver bone morphogenetic protein-2. J Bone Joint Surg Br 2002;84:120–127. Lee JYMD, Musgrave DMD, Pelinkovic DMD, Fukushima KMDP, Cummins JB, Usas AMD, Robbins PP, Fu FHMD, Huard JP: Effect of bone morphogenetic protein-2-expressing musclederived cells on healing of critical-sized bone defects in mice.

Stereotactically injected BMP vectors into the paraspinal musculature is a compelling approach, since multiple, percutaneous injections could be performed to produce a fusion mass with a predetermined three-dimensional shape and in locations specific for each pathological process. Postprocedural pain would be minimal since the technique would not require muscular dissection. Patients requiring neural decompression could be taken to surgery following successful bony fusion, where extensive laminectomies, facetectomies, and foraminotomies could be performed without leading to spinal instability.

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