By Richard G. A. Faragher (auth.), Richard Aspinall (eds.)
During the final forty years, the learn of the organic foundation of getting older has improved vastly, and it has now develop into an self sustaining and first rate box of research and research.
This quantity on "Aging of Organs and Systems", is an try to deliver knowing to either the getting older method and the disorder strategies of previous age. Bringing jointly contributions from a world group of authors, it will likely be of curiosity to graduates and postgraduates within the fields of medication and nursing, researchers of other elements of biogerontology and people within the pharmaceutical, cosmeceutical, nutriceutical and health-care undefined.
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88. 89. 90. 91. 92. 93. 94. 95. 96. 97. 98. 99. 100. 101. 102. 103. 104. 105. 27 Funk WD, Wang CK, Shelton DN, Harley CB, Pagon GD, Hoe¥er WK (2000). Telomerase expression restores dermal integrity to in vitro-aged ¢broblasts in a reconstituted skin model. Exp Cell Res. 258(2): 270^8. Sikora E, Kaminska B, Radziszewska E, Kaczmarek L (1992). Loss of transcription factor AP1 DNA binding activity during lymphocyte aging in vivo. FEBS Lett. 312: 179^ 82. Sheshadri T, Campisi J (1990). Repression of c-fos and an altered genetic programme in senescent human ¢broblasts.
This last section presents two areas in which oxidative damage and cell senescence are clearly interrelated processes. The ¢rst of these is the observation (initially by Thomas von Zglinicki but con¢rmed since in several other laboratories) that by placing cells under mild oxidative stress (mild stress being de¢ned as a stress that still allows some cell proliferation to take place) it is possible to increase the rate at which telomere shortening occurs . Such mild stresses include treatment or hydrogen peroxide or placing the cells under chronic hyperoxia.
Regulation of DNA synthesis in mitotic and postmitotic W138 ¢broblasts in the ¢broblast stem cell system J Cell Biochem. 17D: 152. Wang E, Lee M, Pandey S (1994). Control of ¢broblast senescence and activation of programmed cell death J Cell Biochem. 54: 432^9. Smith JR, Lincoln DW II (1984). Aging of cells in culture. Int Rev Cytol. 89: 151^77. The Relationship Between Cell Turnover and Tissue Aging 45. 46. 47. 48. 49. 50. 51. 52. 53. 54. 55. 56. 57. 58. 59. 60. 61. 62. 63. 64. 65. 66. 25 E¡ros RB, Pawelec G (1997).