Amyotrophic Lateral Sclerosis by M. Maurer

By M. Maurer

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NP001 has been tested in a phase I trial (NCT01091142) for safety and tolerability. It is currently evaluated in a subsequent phase II clinical trial (NCT01281631). 54 Olanzapine Olanzapine is an atypic neuroleptic drug used in psychiatry for the treatment of schizophrenia and other psychoses. One of its effects is also weight gain. In ALS patients, an involuntary weight loss of more than 10 percent of the original body weight correlates with an increased mortality. Thus treatment with olanzapine might increase the body weight, or, at least, keep it constant.

1978). 80 Tocopherol (Vitamin E) The anti-oxidant tocopherol has been evaluated in two phase II clinical trials, where tocopherol has been as add-on medication to riluzole in ALS patients. , 2005). , 2007). 81 Topiramate Topiramate is an anti-convulsant with anti-glutamatergic effects. , 2003). , 1979). 83 Tretinoin (all-trans retinoic acid) Tretinoin is the all-trans form of retinoic acid. , 2009)). In a riluzole add-on phase II study (NCT00919555), tretinoin is currently evaluated in combination with pioglitazone.

11, No. 3, pp. 293-297. , Polymenidou, M. W. (2009). Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond. J Cell Biol, Vol. 187, No. 6, pp. 761772. , Saida, T. & Nishitani, H. (1984). Amyotrophic lateral sclerosis: a double-blind crossover trial of thyrotropin-releasing hormone. J Neurol Neurosurg Psychiatry, Vol. 47, No. 12, pp. 1332-1334. Izumi, Y. & Kaji, R. (2007). [Clinical trials of ultra-high-dose methylcobalamin in ALS]. Brain Nerve, Vol. 59, No. 10, pp. 1141-1147.

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